A long running sotryline will see show Lee Carter battle depression. EastEnders have teamed up with Mind, a mental health charity and the story will unfold next month.
Lee will struggle to cope with everyday life, and sister Nancy will be the first person to nice the changes happening.
Lee opens up to Nancy but he is adamant he doesn't want parents Mick and Linda to find out, especially after the troubles they have had this past year.
Danny-Boy Hatchard, who plays Lee, commented: "This is not a subject that only a handful of people can relate to. It's something that at some point most people in their lives will experience on different levels."
EastEnders has previously been praised for its portrayal of other mental health storylines for characters including Jean Slater and Stacey Branning.
A spokesperson for Mind added: "We have a long history of working with EastEnders and are grateful that they are keen once again to tackle mental health in front of such a large audience.
"Mental health problems are very common, affecting around one in four people, and depression is one of the most common conditions. For some viewers, a dramatic portrayal is the first time they may be exposed to mental health problems and when done well soaps can be a tremendous tool in raising awareness, challenging attitudes and helping to dispel myths.
"In research we carried out last year, we even discovered that 25% of respondents had sought professional help for their own mental health after seeing a soap character with similar issues."
For more information on depression and other mental health problems, visit http://www.mind.org.uk/